Nanion Technologies - Papers & References

Automated Internal Perfusion

Application Notes

Papers, News & Events

2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 and earlier

2010

User Publication: 'Multiplexed transposon-mediated stable gene transfer in human cells'

Kahlig K.M., Saridey S.K., Kaja A., Daniels M.A., George A.L .Jr and Wilson M.H. Proc. Natl. Acad. Sci. USA.
2010, Jan 26;107(4), 1343-8.

User Publication: 'Studying mechanosensitive ion channels using liposomes'

Martinac B., Rohde P.R., Battle A. R., Petrov E., Pal P, Alexander Foo A.FW, Vásquez V., Huynh T. and Kloda A.
Methods Mol. Biol. 2010, 606, 31-53.

2009

User Publication: 'High throughput techniques for discovering new glycine receptor modulators and
their binding sites'

Gilbert D.F.,Islam R., Lynagh T., Lynch J.W., Webb T.I. Front. Mol. Neurosci., 2009, 2(17), 1-10. Epub 2009 Oct 30

User Publication: 'High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1'

Lewis L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D.,
Denton J. Mol. Pharmacol., 2009, 76(5), 1094-1103.

User Publication: 'The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes'

Gaßmann O., Kreir M., Ambrosi C., Pranskevich J., Oshima A, Röling C., Sosinsky G., Fertig N., Steinem C.
Journal of Structural Biology, 2009, 168 (1), 168-176.

User Publication: 'Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases'

Bessac B.F., Sivula M., von Hehn C.A., Caceres A.I., Escalera, J, Jordt S.
FASEB Journal, 2009; 23, 1102-1114.

User Publication: 'Amyloid-beta-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy'

Capone R., Quiroz F.G., Prangkio P., Saluja I., Sauer A.M., Bautista M.R., Turner R.S., Yang J., Mayer M.
Neurotox. Res., 2009, 16(1), 1-13. Epub 2009 Mar 19.

User Publication: 'Robotic multiwall planar patch-clamp for native and primary mammalian cells'

Milligan C.J., Li J., Sukumar P., Majeed Y., Dallas M.L., English A., Emery P., Porter K.E., Smith A.M., McFadzean I.,
Beccano-Kelly D., Bahnasi Y., Cheong A., Naylor J., Zeng F., Liu X., Gamper N., Jiang L., Pearson H.A., Peers C., Robertson B., Beech D.J.
Nature Protocols, 2009, 4(2), 244-255.

'Ion channel screening – automated patch clamp on the rise'

Farre C., George M., Brüggemann A., Fertig N.
Drug Discovery Technology, 2009, Available online 28 January.

'Port-a-Patch and Patchliner: High fidelity electrophysiology for secondary screening and safety pharmacology'

Farre C., Haythornthwaite A., Haarmann C., Stoelzle S., Kreir M., George M., Brüggemann A., Fertig N.
Comb. Chem. & HTS, 2009, 12 (1), 24-37. (1.675kb)

2008

User Publication:'T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin'

Rimoli M.G., Russo E., Cataldi M., Citraro R., Ambrosino P., Melisi D., Curcio A., De Lucia S., Patrignani P., De Sarro G., Abignente E.
Neuropharmacology, 2008, Nov 30., E-publication ahead of print.

Book chapter: 'Planar patch clamp – Advances in electrophysiology'

Brüggemann A., Farre C., Haarmann C., Haythornthwaite A., Kreir M., Stoelzle S., George M., Fertig N.
Methods in Molecular Biology, Potassium channels, Humana Press, 2008, 49, 165-176.

'Planar patch-clamp force microscopy on living cells'

Pamir E., George M., Fertig N., Benoit M.
Ultramicroscopy, 2008, 108(6), 552-557.

User Publication: 'Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells'

Li J., Sukumar P., Milligan C.J., Kumar B., Ma Z.Y., Munsch C.M., Jiang L.H., Porter K.E., Beech D.J.
Circ. Res., 2008 103(8), e97-104.

User Publication: 'Production of a specific extracellular inhibitor of TRPM3 channels'

Naylor J., Milligan C.J., Zeng F., Jones C., Beech D.J.
British Journal of Pharmacology, 2008, 1–7. (358kb)

User Publication: 'TRPC channel activation by extracellular thioredoxin'

Xu S.Z., Sukumar P., Zeng F., Li J., Jairaman A., English A., Naylor J., Ciurtin C., Majeed Y., Milligan C.J., Bahnasi Y.M., Al-Shawaf E., Porter K.E., Jiang L.H., Emery P., Sivaprasadarao A., Beech D.J.
Nature, 2008 451(7174), 69-72.

User review of planar electrophysiological devices: 'High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology'

Dunlop J., Bowlby M., Peri R., Vasilyev D., Arias R.
Nature Reviews Drug Discovery, 2008, 7, 358-368.

User Publication: 'TRPA1 is a major oxidant sensor in murine airway sensory neurons'

Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E.
J. Clin. Invest., 2008, 118(5), 1899-1910

User Publication: 'Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3'

Cianci J., Baell J.B., Flynn B.L., Gable R.W., Mould J.A., Paul D., Harvey A.J.
Bioorganic & Med. Chem. Lett., 2008, 18, 2055–2061.

'Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes'

Kreir M., Farre C., Beckler M., George M., Fertig N.
Lab-on-a-Chip, 2008, 8(4), 587-95.

(306kb)

2007

User Publication: 'Electrophysiological assessment of HERG blockade: Comparative study using automated and conventional patch clamp systems'

Yook Y., Kim J., Cho H., Moon H., Kwak B.
Toxicology Letters, 2007, 172 (Suppl.1), S98-S99.

Book chapter: 'Planar Patch Clamping'

Behrends, J.C., Fertig, N.
Patch Clamp Analysis – Advanced Techniques, Series: Neuromethods, Springer, 2007, 38, 411-433.

(4.949kb)

'Automated ion channel screening: patch clamping made easy'

Farre C., Stoelzle S., Haarman C., George M., Brueggemann A., Fertig N.
Expert Opinion Therapeutic Targets, 2007, 11(4), 557-565.

(936kb)

2006

'Microchip technology for automated and parallel patch clamp recording'

Brüggemann A., Stoelzle S., George M., Behrends J.C., Fertig N.
Small, 2006, 2(7), 840 – 846.

(529kb)

'High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation'

Sondermann M., George M., Fertig N., Behrends J.C.
Biochimica et Biophysica Acta 1758, 2006, 545–551.

(362kb)

2005

'Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles'

Kirchner C., Liedl T., Kudera S., Pellegrino T., Munoz J. A., Gaub H.E., Stoelzle S., Fertig N., Parak W.J.
Nano Lett., 2005, 5(2), 331-338.

(1.374kb)

'The Port-a-Patch: The smallest patch clamp set up for high quality electrophysiology'

Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J., Fertig N.
HEKA impulse 03, 2005, 2-4.

(370kb)

2004 and earlier

'Ion channel drug discovery and research: The automated Nano-Patch-Clamp technology'

Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.
Current Drug Discovery Technologies, 2004, 1(1), 91-96.

(137kb)

'High quality ion channel analysis on a chip with the NPC-technology'

Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.
Assay and Drug Development Technologies, 2003, 1(5), 665-673.

(527kb)

'Microstructured apertures in planar glass substrates for ion channel research'

Fertig N., Meyer C., Tilke A., George M., Klau M., Sobotta C., Blick R.H., Behrends J.C.
Channels and Receptors, 2003, 9(1), 29-40.

'Simultaneous optical and electrical recording of single gramicidin channels'

Borisenko V., Lougheed L., Hesse J., Fuereder-Kitzmueller E., Fertig N., Behrends, J.C., Woolley G.A., Schuetz G.J.
Biophys. J., 2003, 84, 612-622.

(385kb)

New Notable: 'Lighting up single ion channels'

Biophys. J.; 2003, 84(Jan), 1-2.

(40kb)

'Activity of single ion channel proteins detected with a planar microstructure'

Fertig N., Klau M., George M., Blick R.H., Behrends J.C.
APL, 2002, 81(25), 4865-67.

(99kb)

'Whole cell patch clamp recording performed on a planar glass chip'

Fertig N., Blick R.H., Behrends J.C.
Biophys. J., 2002, 82(6), 3056-62.

New Notable: 'Patch clamp on a chip'

Biophys. J., 2002, 82(Jun), 2831-2832.

(23kb)

'Microstructured glass chip for ion channel electrophysiology'

Fertig N., Meyer C., Blick R.H., Trautmann C., Behrends J.C.
Physical Review E, 2001, 64, 040901 R.

(328kb)

'Stable integration of isolated cell membrane patches in a nanomachined aperture: A step towards a novel device for membrane physiology'

Fertig N., Tilke A., Blick R.H., Kotthaus J.P., Behrends J.C., ten Bruggencate G.
APL, 2000, 77(8), 1218-20.

(643kb)