Nanion's new Internal Perfusion System for the Port-a-Patch allows for rapid, continuous and automated exchange of internal solutions during patch clamp recordings.
Using the internal perfusion system, ion channels regulated by internal binding sites for second messengers can be easily modulated or compounds acting on the internal side of the membrane like e.g. hERG active substances can be directly applied internally.

The Automated Internal Perfusion System is an add-on to the Port-a-Patch with a dedicated chip holder containing fluidics and a specially designed shielding compartment with an inverted electrode arrangement for bath and reference electrode. The Internal Perfusion System is a 'plug-and-play' device, fully compatible the Port-a-Patch as well as Nanion's 8-channel perfusion system.

The ability to change the internal solution several times, along with long lasting and stable whole cell or bilayer recordings possible with the Port-a-Patch, opens up to new experimental possibilities for a broad range of ion channel studies and will prove to be a useful tool in ion channel research.