• Nanion Technologies: Smart Tools for Ion Channel Research

    Nanion Technologies: Smart Tools for Ion Channel Research

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: Label-free HTS Transporter Screening

    SURFE²R 96SE: Label-free HTS Transporter Screening

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • Bilayer recordings: Orbit product family

    Bilayer recordings: Orbit product family

  • CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

    CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

Our Product Portfolio

SyncroPatch 384

SyncroPatch 384

Patchliner

Patchliner

Port-a-Patch

Port-a-Patch

Port-a-Patch mini

Port-a-Patch mini

CardioExcyte 96

CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

SURFE²R 96SE

SURFE²R 96SE

SURFE²R N1

SURFE²R N1

Orbit 16 TC

Orbit 16 TC

Orbit Mini

Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

Buffer Solution

Buffer Solution

Orbit mini - Plug and Paint

The Orbit mini is a miniaturized bilayer workstation enabling the recording of four artificial lipid bilayers simultaneously. The benefits the Orbit mini setup offers include:

  • Standalone turn-key system with extremely small footprint
  • Integrated four channel low-noise amplifier
  • Optional temperature control - automated active cooling and heating
  • Low noise recordings at highest bandwidths
  • Increased throughput due to four simultaneous recordings
  • Dedicated comprehensive recording software included
  • Target molecules can be introduced directly or by fusion of (proteo-)liposomes
  • Ion channels: voltage and ligand gated, temperature sensitive
  • Nanopores, antimicrobial peptides, toxins and many more...
  • Cost-efficient experiments with disposable MECA chips

The Orbit mini contains a built-in, miniaturized four-channel amplifier, allowing low noise recordings at high bandwidth without the need for any additional equipment – you could virtually conduct experiments while travelling by train! Due to the unique design of the Orbit mini, the measurement chamber temperature can be actively controlled without additional noise generation.

The complete Orbit mini platform consists of the main recording unit with a built-in four channel amplifier (Elements s.r.l.), and an optional computer-controlled environmental control unit for active cooling and heating of the recording chamber. Ionera's MECA 4 disposable recording chips are used for manual painting and recording of four artificial lipid bilayers in parallel.  

For detailed information:

Add-Ons and Features

Temperature Control Unit

With the temperature control unit, temperatures on the chip can be varied in between 0°C to 50°C, as it contains an active cooling and active heating function.

temperature control Orbit

Temperature control of the Orbit mini: PEG induced current blockages of a alpha-hemolysin pore

(A) Current traces recorded at 10°C and 40°C illustrating a strong increase of the open pore current as well as the blockage frequency at elevated temperature.
(B) Event averaged histograms of the residual current during blockages. The open pore current scales with the temperature as well as the dwell time of the blockages.
(C) Dependence of the open pore current on the temperature.
(D) Dependence of the frequency of blockages on the temperature.

The image war kindly provided by Ionera Technologies GmbH


Orbit mini Fluorescence Microscopy Kit

For fluorescence applications, the Orbit mini can be equipped with the "Fluorescence Microscopy Kit" which includes an adapted faraday shielding as well as "Meca 4 Recording Chips Fluo", four-well recording chips for fluorescence applications with 150 µm cavity size (Order # 132004).

Software

Orbit mini EDR Software

eFOUR Software

The software for the Orbit mini was developed by our partner Elements SRL (Italy). It is intuitive and easy to learn. Please watch this video on the Orbit mini to learn about the software:


Software Updates:

Please download EDR Software Updates from the Elements s.r.l homepage, out partner for Orbit mini software tools. Click here for Software downloads.

Consumables

MECA 4 Recording Chips

The MECA recording substrate contains a 2 x 2 array of circular microcavities in a highly inert polymer. Each cavity contains an individual integrated Ag/AgCl-microelectrode. The bilayer is formed by painting, with high success rates for functional bilayers. The MECA chip has been validated with a number of different ion channels including KcsA, gramicidin, α-hemolysin, KV1.3, NaV and many more.

The MECA recording chips are produced and quality assured by our partner Ionera Technologies GmbH in Freiburg Germany and shipped from Munich to our international customers. Different types of MECA recording chips are available which should be chosen depending on experiment.

MECA 4 1


Available chip types
  • "Meca 4 Recording Chips 50 µm": Four-well recording chip with 50 µm cavity size (Order # 132001)
  • "Meca 4 Recording Chips 100 µm": Four-well recording chip with 100 µm cavity size (Order # 132002)
  • "Meca 4 Recording Chips 150 µm": Four-well recording chip with 150 µm cavity size (Order # 132003)
  • "Meca 4 Recording Chips Fluo": Four-well recording chip for fluorescence applications with 150 µm cavity size (Order # 132004)

Testimonials & Case Studies

Data and Applications

Product and Tutorial Movies

Webinars and Presentations

Downloads:

Application Notes

Product Sheets

Quickstart Guides

Publications

Posters

 

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