• Nanion Technologies: Smart Tools for Ion Channel Research

    Nanion Technologies: Smart Tools for Ion Channel Research

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: Label-free HTS Transporter Screening

    SURFE²R 96SE: Label-free HTS Transporter Screening

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • Bilayer recordings: Orbit product family

    Bilayer recordings: Orbit product family

  • CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

    CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

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SyncroPatch 384i

SyncroPatch 384i

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CardioExcyte 96

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FLEXcyte 96

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SURFE²R N1

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Orbit 16

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Orbit Mini

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Vesicle Prep Pro

2017 - High throughput real-time measurement of electrogenic membrane transport driven by the SLC transporters PepT1 and OcT2

Icon 96SE   SURFE²R SE96 poster, Biophysics congress 2017  logo pdf   (1.8 MB)

 Abstract:

“Solid Supported Membrane (SSM) based electrophysiology” is an established method, developed at the Max-Plank-Institut, which allows to record low amplitude electrogenic events with a high amplification. The method allows real-time activity measurement of targets for which  onventional electrophysiology is unsuitable, like many electrogenic membrane transporters and pumps, or targets localized in intracellular or bacterial membranes.

Here, we present pharmacological and functional studies of different transporters and channels (PepT1, OCT2, NCX1, AChR alpha 7, mitochondrial F-type ATPase, XyIE, Channel rhodopsin 2), analyzed on the SURFE²R 96SE device.

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