• Nanion Technologies: Smart Tools for Ion Channel Research

    Nanion Technologies: Smart Tools for Ion Channel Research

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: Label-free HTS Transporter Screening

    SURFE²R 96SE: Label-free HTS Transporter Screening

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • Bilayer recordings: Orbit product family

    Bilayer recordings: Orbit product family

  • CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

    CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

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SyncroPatch 384i

SyncroPatch 384i

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Patchliner

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Port-a-Patch

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Port-a-Patch mini

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CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

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SURFE²R 96SE

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SURFE²R N1

Orbit 16

Orbit 16

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Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

2005 - The Port-a-Patch: The smallest patch clamp set up for high quality electrophysiology

icon pap  Port-a-Patch publication in HEKA Impulse (2005)

Authors: 
Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J., Fertig N.

 

Journal: 
HEKA impulse 03, 2005, 2-4.


Abstract: 

In evaluating ion channel function, patch clamping, provides the highest information content but every electrophysiologist knows the draw back of the size and complexity of a patch clamp rig. We present here patch clamp recordings in the whole cell con- figuration performed with planar patch clamp chips, which are micro- structured from borosilicate glass substrate. The chips are used in the Port-a-Patch, a simplified and miniaturized patch clamp setup that enables automated patch clamp experiments on a single cell. The PatchMaker software performs the experiment by executing user-determined protocols for cell positioning and in communication with the PULSE software also protocols for electrical stimulation and current readout. In various electro- physiological experiments, the high quality of recordings and the versatility of the perfusion of the recorded cells are demonstrated.


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