P2X2/ P2X3 - Block by suramin on the SyncroPatch 384PE
SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were engineered and kindly supplied by Axxam
P2X2/3 recorded from CHO cells on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384). P2X2/3 was activated by 10 µM ATP and blocked by increasing concentrations of suramin with an IC50 = 17.7 ± 0.9 µM (n = 372). Average traces and concentration response curve shown for 372 cells. Success rate was 97% for completed experiment (372 wells from a possible 384). Multi-hole (4 holes per well) chips were used.
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