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14.10.2020 | Webinar: Development and validation of ASIC1a ligand-gated ion channel drug discovery assays on automated patch clamp platforms.

icon sp96  SyncroPatch 384i and icon pl Patchliner Webinar

Date: October 14. 2020

201012 Blog Image VUM 2020

Speakers:

Dr. Marc Rogers (Metrion Biosciences; U.K.)


This is an on-demand webinar from Nan]i[on and Friends 2020.

Abstract:

Whilst voltage-gated ion channels formed the bulk of academic and industrial effort in developing and utilising APC assays for ion channel drug discovery, recent years have seen increasing interest in ligand-gated receptors. These targets offer specific challenges for APC systems in terms of lower channel expression, rapid application and wash-off of ligands, and loss of responsiveness due to short- and long-term desensitisation. In this presentation I will outline successful development of pipette- and tip-based APC assay formats for the rapidly-activating ASIC1A channel on the Patchliner and SyncroPatch384i.


 

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