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2021 - Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome

icon sp96 SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) publication in Biological Psychiatry (2021)

Authors:
Hwang H., Szucs M.J., Ding L.J., Allen A., Ren X., Haensgen H., Gao F., Rhim H., Andrade A., Pan J.Q., Carr S.A., Ahmad R., Xu W.

Journal:

Biological Psychiatry (2021) doi: 10.1016/j.biopsych.2020.07.014


Abstract: 

Neurogranin (Ng), encoded by the schizophrenia risk gene NRGN, is a calmodulin-binding protein enriched in the postsynaptic compartments, and its expression is reduced in the postmortem brains of patients with schizophrenia. Experience-dependent translation of Ng is critical for encoding contextual memory, and Ng regulates developmental plasticity in the primary visual cortex during the critical period. However, the overall impact of Ng on the neuronal signaling that regulates synaptic plasticity is unknown.


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