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    Nanion Technologies: Smart Tools for Ion Channel Research

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    SyncroPatch 384i: HTS Automated Patch Clamp

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    SURFE²R 96SE: Label-free HTS Transporter Screening

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

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    Bilayer recordings: Orbit product family

  • CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

    CardioExcyte 96 SOL: Pacing Cardiomyocytes with Light

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Orbit 16 TC

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Vesicle Prep Pro

2021 - Drug Effects on human Na+/Ca2+ Exchanger and Implications for Drug Development

Icon CE   FLEXcyte 96 and   Icon N1  SURFE²R N1 and   Icon 96SE   SURFE²R 96SE poster, Biophysical Society Meeting 2021  logo pdf   (1.3 MB)

Abstract:

The Na+/Ca2+-exchanger (NCX) plays an important role in cellular calcium homeostasis under physiological but also pathological conditions. The pharmacological potential and risks of NCX have been debated for many years. The consequences of changes in activity and mode of operation of NCX are still discussed. Mostly a potential beneficial effect of NCX reverse mode inhibition under ischemic conditions has been suggested. There is ongoing effort to find specific and direction-specific NCX inhibitors, but inadvertent NCX inhibition is usually not tested during drug development.

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