SyncroPatch 384PE and Patchliner article in Nature Scientific Reports (2020)
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
SyncroPatch 384PE and Patchliner article in Toxicology and Applied Pharmacology (2020)
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Patchliner publication in European Journal of Medicinal Chemistry (2020)
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Patchliner publication in British Journal of Pharmacology (2020)
Pharmacological and genetic characterisation of the canine P2X4 receptor.
Patchliner publication in The Faseb Journal (2020)
A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function.
Patchliner publication in Phytochemistry (2020)
An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors.
Patchliner publication in Biochemical Pharmacology (2020)
Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom.
Patchliner and Dynamite8 publication in Current Protocols in Pharmacology (2020)
Automated Dynamic Clamp for Simulation of IK1 in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Real Time Using Patchliner Dynamite8
SyncroPatch 384PE, Patchliner and Port-a-Patch review article in Current Protocols in Pharmacology (2019)
Role of High‐Throughput Electrophysiology in Drug Discovery.
Patchliner and Dynamite8 publication in Stem Cell Research (2019)
Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs.
Patchliner book chapter in Purinergic Signaling (2020)
Automated Planar Patch-Clamp Recording of P2X Receptors.
Patchliner publication in Fitoterapia (2019)
GIRK channel activity of Hungarian mushrooms: From screening to biologically active metabolites.
Patchliner publication in Frontiers in Cellular Neuroscience (2019)
A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family.
Patchliner publication in Natural Product Communications (2019)
Isolation and Pharmacological Investigation of Compounds From Euphorbia matabelensis.
Patchliner publication in Frontiers in Physiology (2019)
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Patchliner publication in CNS Neuroscience & Therapeutics (2019)
Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity
Patchliner publication in Journal of Chemoinformatics (2019)
Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial setting
Patchliner publication in ACS Medicinal Chemistry Letters (2019)
Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs
Patchliner publication in Cell Stem Cell (2019)
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo