• Aerolysin

    Screenshot s of a typical channel forming aerolysin activity assay with the Orbit 16.


Pore-forming Toxins

Aerolysin is a cytolytic pore-forming toxin exported by Aeromonas hydrophila, a Gram-negative bacterium.

The mature protein forms a heptamer.

The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis.



2020 - Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore

Icon Orbit  Orbit 16 publication in Nature Biotechnology (2020)

Ouldali H., Sarthak K., Ensslen T., Piguet F., Manivet P., Pelta J., Behrends J.C., Aksimentiev A., Oukhaled A.

2019 - A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters

Icon Orbit   Orbit 16 publication in The European Physical Journal E (2019)

Wang H., Kasianowicz J.J., Robertson J.W.F., Poster D.L., Ettedgui J.

2018 - Size-dependent interaction of a 3-arm star poly(ethylene glycol) with two biological nanopores

Icon Orbit   Orbit 16 publication in The European Physical Journal E (2018)

Talarimoghari M., Baaken G., Hanselmann R., Behrends J.C.

2016 - Probing driving forces in aerolysin and α-hemolysin biological nanopores: electrophoresis versus electroosmosis

Icon Orbit  Orbit 16 publication in Nanoscale (2016)

Boukhet M., Piguet F., Ouldali H., Pastoriza-Gallego M., Pelta J., Oukhaled A.

2015 - High-Resolution Size-Discrimination of Single Nonionic Synthetic Polymers with a Highly Charged Biological Nanopore

Icon Orbit  Orbit 16 and   icon vpp   Vesicle Prep Pro publication in American Chemical Society Nano (2015)

Baaken G., Halimeh I., Bacri, Pelta J., Oukhaled A., Behrends J.C.


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