Non-ribosomally Synthesized Channels
Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides, which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid).
Chemically, the peptaibol is a peptide of 20 amino acids and forms a alpha-helical structure. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.
Data and Applications