Alpha-hemolysin is secreted by Staphylococcus aureus, this toxin causes cell death by binding with the outer membrane,
Alpha-hemolysin forms a homo-heptameric β-barrel in biological membranes.
Hemolysins are thought to be responsible for many events in host cells. For example, iron may be a limiting factor in the growth of various pathogenic bacteria. Since free iron may generate damaging free radicals, free iron is typically maintained at low concentrations within the body. Red blood cells are rich in iron-containing heme. Lysis of these cells releases heme into the surroundings, allowing the bacteria to take up the free iron.
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