ANT1 - ADP/ATP Translocase 1 - SLC25A4
ADP/ATP translocase family, also known as adenine nucleotide translocases (ANT) and ADP/ATP carrier proteins (AAC)
There are four knowm members of the ANT family expressed in humans: SLC25A4 (ANT 1), SLC25A5 (ANT 2), SLC25A6 (ANT 3) and SLC25A31 (ANT 4)
ANT 1 is the major ANT transporter in human cells and the archetypal protein of this family. It contains six transmembrane α-helices that form a barrel that results in a deep cone-shaped depression accessible from the outside where the substrate binds.
The transporter proteins enable the exchange of cytosolic adenosine diphosphate (ADP) and mitochondrial adenosine triphosphate (ATP) across the inner mitochondrial membrane. Free ADP is transported from the cytoplasm to the mitochondrial matrix, while ATP produced from oxidative phosphorylation is transported from the mitochondrial matrix to the cytoplasm, thus providing the cells with its main energy currency.