Bestrophin-1 | BEST1

Calcium-dependent chloride channels (Ca-CIC or CaCC family)

CaCCs that are known to occur in humans are encoded by the following genes:
Accessories: CLCA1 - CLCA4
Anoctamins: ANO-1 and ANO-2
Bestrophins: BEST1 - BEST4

CaCC channels are a heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells, including proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels. Members of the Ca-CIC family exhibit 7 to 10 transmembrane segments.


2018 - An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1

icon pap   Port-a-Patch publication in Journal of General Physiology (2018)

Vaisey G., Long S.B.

2016 - Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel

icon pap  Port-a-Patch publication in Proceedings of the National Academy of Sciences of the United States of America (2016)

Vaisey G., Miller A.N., Long S.B.



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