• ClC-1

    Tail currents of ClC-1 expressed in CHO cells inhibited by increasing concentration of 9-AC on the SyncroPatch 384PE

  • Ec-ClC

    Typical Ec-ClC current response on the SURFE2R N1 (left) when chloride is applied to the sensor and the corresponding concentration response curve for chloride (right).

ClC-1 – Inhibition by 9-AC

ClC 1 figure Inhibition by 9 ACicon sp96   SyncroPatch 384i data and applications:
Cells were kindly provided by Charles River.

Tail currents of ClC-1 expressed in CHO cells were inhibited by increasing concentration of 9-AC. A single concentration of 9-AC was added to each well and the concentration response curve constructed over multiple wells. The IC50 was calculated to be 6.3 µM for an average of 352 wells. The average current traces are also shown.

 

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