CNT1 - Concentrative Nucleoside Transporter 1 - SLC28A1

Concentrative Nucleoside Transporter (CNT) family

Subgroups and Members:
The 7 known human nucleosides transporters (hNTs) exhibit varying permeant selectivities and are found into 2 protein families: the solute carrier (SLC) 29 (SLC29A1, SLC29A2, SLC29A3, SLC29A4) and SLC28 (SLC28A1, SLC28A2, SLC28A3) proteins, otherwise known, respectively, as the human equilibrative NTs (hENTs, hENT1, hENT2, hENT3, hENT4) and human concentrative NTs (hCNTs, hCNT1, hCNT2, hCNT3).

Sequenced members of the CNT family are derived from Gram-negative and Gram-positive bacteria as well as yeast and animals. They are of about 400 residues (bacterial) or about 600-700 residues (eukaryotes) with 10-14 transmembrane α-helical spanners.

Nucleoside transporters are a group of membrane transport proteins which transport nucleoside substrates like adenosine across the membranes of cells and/or vesicles

a.      P-bond hydrolysis driven transporters

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