CpnT - Outer Membrane Channel Protein CpnT

Outer membrane Channel Proteins

CpnT is expressed by the Mycobacterium tuberculosis. CpnT has a dual function in uptake of nutrients and induction of host cell death.

Topology and Function:
CpnT consists of two domains. The oligomeric N-terminal domain (NTD) forms an outer membrane channel and is required for efficient glycerol uptake. The toxic C-terminal domain (CTD) is cleaved and secreted and acts as a glycohydrolase, which hydrolyzes the essential cellular coenzyme NAD+ in the cytosol of infected macrophages, leading to necrotic host cell death. Both functions are required for survival, replication and cytotoxicity of M.tuberculosis in macrophages.


2014 - An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Proceedings of the National Academy of Sciences of the United States of America (2014)

Danilchanka A., Sun J., Pavlenok M., Maueröder C., Speer A., Siroy A., Marrero J., Trujillo C., Mayhew D.L., Doornbos K.S., Muñoz 'L.E., HerrmannM., EhrtS., Berens C., Niederweisa M.


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