CpnT - Outer Membrane Channel Protein CpnT

Family:
Outer membrane Channel Proteins

Description:
CpnT is expressed by the Mycobacterium tuberculosis. CpnT has a dual function in uptake of nutrients and induction of host cell death.

Topology and Function:
CpnT consists of two domains. The oligomeric N-terminal domain (NTD) forms an outer membrane channel and is required for efficient glycerol uptake. The toxic C-terminal domain (CTD) is cleaved and secreted and acts as a glycohydrolase, which hydrolyzes the essential cellular coenzyme NAD+ in the cytosol of infected macrophages, leading to necrotic host cell death. Both functions are required for survival, replication and cytotoxicity of M.tuberculosis in macrophages.

Publications

2014 - An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Proceedings of the National Academy of Sciences of the United States of America (2014)

Authors: 
Danilchanka A., Sun J., Pavlenok M., Maueröder C., Speer A., Siroy A., Marrero J., Trujillo C., Mayhew D.L., Doornbos K.S., Muñoz 'L.E., HerrmannM., EhrtS., Berens C., Niederweisa M.

 

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