ENaC | Epithelial Sodium Channel | Amiloride-sensitive Sodium Channel
Epithelial sodium channels, member of the ENaC/Degenerin superfamily
ENaC is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ. These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D. As a typical member of the ENaC/Degenerin superfamily, each of the subunits consists of two transmembrane helices and an extracellular loop.
ENaC is located in the apical membrane of polarized epithelial cells in particular in the kidney (primarily in the distal tubule), the lung, and the colon facilitating Na⁺ reabsorption across the apical membranes of epithelial cells.
Data and Applications