• ENaC

    Cumulative dose-dependent block of ENaC by Amiloride, measured on the SyncroPatch 96, a predecessor model of the SyncroPatch 384PE

ENaC - Epithelia Sodium Channel Analysis

SP96 Enac Amiloride

icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) data and applications:

The data present cumulative dose-dependent block of ENaC by Amiloride. Currents were obtained performing ramps -100mV/100mV every 2 s from a Vhold=-40mV. The large window shows the effect of increasing concentrations (1 µM, 10µM, 100µM) of Compound on the ENaC currents. The IC50 with Amiloride was 2.3 µM. Data were collected with a success rate of ~70 %.


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