GABAA Receptor Alpha 1 Beta 2 Gamma 2
Family:
GABA Receptors (Cys-loop ligand-gated ion channels)
Subgroups:
The GABA receptor family has further been divided into GABAA, GABAB and GABAA-ρ (also called GABAC) receptors.
Topology:
As typical for Cys-loop receptors, generally four transmembrane spanning domains TM1-TM4 form one receptor subunit, five or four subunits form a pore, several heteromeric combinations are known.
GABAA: Oligomerization of typically five subunits, heteromeric combinations are known of α subunits (GABRA1 - GABRA6), β subunits (GABRB1 - GABRB3) and γ subunits (GABRG1 - GABRG3), as well as δ (GABRD), an ε (GABRE), a π (GABRP), and a θ (GABRQ). The most common type is (α1)2(β2)2(γ2), minimal requirement is the inclusion of α and β subunits.
GABAB: Heterodimer (GABBR1, GABBR2)
GABAA-ρ: Oligomerization of five subunits, heteromeric combinations of three GABAA-ρ subunits are known (GABRR1, GABRR2, GABRR3)
Regulation and Function:
GABAA and GABAA-ρ receptors are ligand-gated ion channels (ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors (metabotropic receptors). All respond to the neurotransmitter gamma-aminobutyric acid (GABA), the main inhibitory transmitter in the mammalian CNS.
Data and Applications
Application Notes
Publications
GABAA: Further Readings
Patchliner publication in Biotechnology Letters (2021)
Authors:
Shekdar K., Langer J., Venkatachalan S., Schmid L., Anobile J., Shah P., Lancaster A., Babich O., Dedova O., Sawchuck D.
SyncroPatch 96 (a predecessor model of the SyncroPatch 384i) Publication in Journal of Vascular Research (2020)
Authors:
Yim P.D., Gallos G., Lee-Kong S.A., Dan W., Wu A.D., Xu D., Berkowitz D.E., Emala C.W.
SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Lab Automation (2016)
Authors:
Obergrussberger A., Brüggemann A., Goetze T.A., Rapedius M., Haarmann C., Rinke I., Becker N., Oka T., Ohtsuki A., Stengel T., Vogel M., Steindl J., Mueller M., Stiehler J., George M., Fertig N.
Patchliner,
SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) and
CardioExcyte 96 publication in Channels (2015)
Authors:
Obergrussberger A., Stölzle-Feix S., Becker N., Brüggemann A., Fertig N., Möller C.
Port-a-Patch publication in Nature (2014)
Authors:
Miller P.S., Aricescu A.R.
Patchliner publication in Journal of Biomolecular Screening (2012)
Authors:
Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, Brüggemann A, Fertig N.
Port-a-Patch and
Patchliner publication in Combinatorial Chemistry & High Throughput Screening (2009)
Authors:
Farre C., Haythornthwaite A., Haarmann C., Stoelzle S., Kreir M., George M., Brüggemann A., Fertig N.
Port-a-Patch and
Patchliner publication in Expert Opinion Therapeutic Targets (2007)
Authors:
Farre C., Stoelzle S., Haarman C., George M., Brueggemann A., Fertig N.
Port-a-Patch and
Patchliner publication in Small Journal (2006)
Authors:
Brüggemann A., Stoelzle S., George M., Behrends J.C., Fertig N.