• GluA2

    Concentration dependent activation of GluA2 receptors by L-Glutamate, measured on the SyncroPatch 384PE

AMPA Receptor (GluA2) - Inhibition by CNQX

icon pl  GluA2_CNQX_SB_PLPatchliner data and applications:
Cells were kindly provided by SB Drug Discovery.

The AMPA receptor (GluA2) was blocked by CNQX on the Patchliner. CNQX was pre-incubated and then co-applied with glutamate. CNQX blocked the GluA2-mediated response in a concentration dependent manner and the potency was dependent on glutamate concentration (left). Exemplar GluA2-mediated responses are shown on the right activated by 100 µM glutamate and inhibited by increasing concentrations of CNQX.

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