NR2B | GluN2B | Glutamate Receptor Ionotropic, NMDA 2B

Family:
Glutamate Receptors

Subgroups:
The Glutamate receptor family has further been divided into ionotropic and metabotropic glutamate receptors. 
The metabotropic glutamate receptor subfamily contains 8 members (mGluR1 - mGluR8)
The ionotropic glutamate receptors subfamily contains 16 members: 
AMPA receptors: GluA1 (GluR1) - GluA4 (GluR4)
Kainate receptors: GluK1 (GluR5), GluK2 (GluR6), GluK3 (GluR7) , GluK4 (KA-1), GluK5 (KA-2)
NMDA receptors: GluN1 (NR1), GluN2A (NR2A), GluN2B (NR2B), GluN2C (NR2C), GluN2D (NR2D), GluN3A (NR3A), GluN3B (NR3B)

Regulation and Function:
Ionotropic glutamate receptors are ligand-gated nonselective cation channels that allow the flow of K+, Na+ and sometimes Ca2+ in response to glutamate binding. Metabotropic glutamate receptors belong to the subfamily C of G protein-coupled receptors. Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.

Application Notes

NMDA Receptors (NR1/NR2A & NR1/NR2B) - "Activation and Inhibition of human NMDA Channels on Nanion`s SyncroPatch 384PE"

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) application note   logo pdf   (3.0 MB)
Cells were kindly provided by Charles River.

Posters

2017 - Pharmacological Characterization of the NMDA A-B-C by Automated Patch Clamp

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) poster, BPS Meeting 2017  logo pdf   (4.9 MB)

Publications

2019 - NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy

icon pap   Port-a Patch Publication in Cancers (2019)

Authors:
Müller-Längle A., Lutz H., Hehlgans S., Rödel F., Rau K., Laube B.

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