• GlyR a1

    Glycine-mediated current traces and corresponding time plots, measured on the SyncroPatch 384PE

Glycine Receptor (GlyRa1) - Accurate Pharmacology

p36 4 glycineicon pl   Patchliner data and applications: 
Cells were kindly provided by AstraZeneca.

Two different application protocols were used to study the effect of exposure time on glycine receptor pharmacology for cells expressing hGlyRα1. As shown from the raw data traces and corresponding Hill plots, the highest concentration, 3 mM glycine, did not elicit the maximum peak response during long exposures (22 s), in contrast to stacked applications (1 s).

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