• GlyR a3

    Effects of indicated concentrations of 3 on α1 and α3 GlyR currents activated by EC20 glycine concentrations, measured on the Patchliner

GlyR a3 | Glycine Receptor Alpha 3

Family:
Glycine receptors (cys-loop receptors)

Subgroups:
There are presently four known isoforms of the α-subunit (α1-4) of GlyR that are essential to bind ligands (GLRA1, GLRA2, GLRA3, GLRA4) and a single β-subunit (GLRB).

Topology:
As typical cys-loop receptors, glycine receptor subunits contain four transmembrane spanning domains TM1-TM4. Five subunits form a pore, homomeric and heteromeric combinations are possible. There are presently four known isoforms of the α-subunit (α1 - α4), encoded by the genes GLRA1 - GLRA4, and a single β-subunit (GLRB)

Data and Applications

Glycine Receptor (GlyRa1 & GlyRa3) - Dose Response Analysis

PLGlycineLynch

icon pl   Patchliner data and applications:

(A) Effects of indicated concentrations of 3 on α1 and α3 GlyR currents activated by EC20 glycine concentrations as indicated. Unfilled bars denote glycine applications and filled bars denote compound applications. (B & C) Average dose response curves of 3 at α1 and α3 GlyRs, respectively.
Data are taken from Balansa W. et al., Bioorg Med Chem. 2010 Apr 15;18(8):2912-9.

 

Publications

2010 - Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

icon pl  Patchliner publication in Bioorganic & Medical Chemistry (2010)

Authors: 
Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Webb TI, Gilbert DF, Lynch JW, Capon RJ.

2009 - High throughput techniques for discovering new glycine receptor modulators and their binding sites

icon pl  Patchliner publication in Frontiers in Molecular Neuroscience (2009)

Authors: 
Gilbert D.F.,Islam R., Lynagh T., Lynch J.W., Webb T.I. Front.

 

 

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