HCN4 | Potassium/Sodium Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4
Family:
Hyperpolarization-activated cyclic nucleotide-gated channels
Subgroups:
Four different members HCN1-HCN4
Topology:
The channel protein contains six transmembrane domains (S1–S6), four subunits form a functional channel, homotetramers and heterotetramers are possible
Function:
Nonselective gated cation channels, referred to as pacemaker channels, rhythmicity in brain and heart cells
Publications
2012 - Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP
Port-a-Patch publication in Journal of Biological Chemistry (2012)
Authors:
Zong X., Krause S., Chen C.C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C., Biel M.