• HCN4

    cCMP effect on the activation of HCN1 - HCN4 channels (measured on the Port-a-Patch)

    Zong et al. (2012)

HCN4 | Potassium/Sodium Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4

Family:
Hyperpolarization-activated cyclic nucleotide-gated channels

Subgroups:
Four different members HCN1-HCN4

Topology:
The channel protein contains six transmembrane domains (S1–S6), four subunits form a functional channel, homotetramers and heterotetramers are possible

Function:
Nonselective gated cation channels, referred to as pacemaker channels, rhythmicity in brain and heart cells

Publications

2012 - Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2012)

Authors: 
Zong X., Krause S., Chen C.C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C., Biel M.

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