• HCN4

    cCMP effect on the activation of HCN1 - HCN4 channels (measured on the Port-a-Patch)

    Zong et al. (2012)

HCN4 | Potassium/Sodium Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4

Hyperpolarization-activated cyclic nucleotide-gated channels

Four different members HCN1-HCN4

The channel protein contains six transmembrane domains (S1–S6), four subunits form a functional channel, homotetramers and heterotetramers are possible

Nonselective gated cation channels, referred to as pacemaker channels, rhythmicity in brain and heart cells


2019 - Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

icon pap   Port-a Patch and Internal Perfusion Publication in JCI Insight (2019)

Hammelmann, V., Stieglitz, M.S., Hülle, H., Le Meur, K., Kass, J., Brümmer, M., Gruner, C., Rötzer, R.D., Fenske, S., Hartmann, J., Zott, B., Lüthi, A., Spahn, S., Moser, M,, Isbrandt, D., Ludwig, A., Konnerth, A., Wahl-Schott, C., Biel M.

2012 - Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2012)

Zong X., Krause S., Chen C.C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C., Biel M.

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