HCN4 | Potassium/Sodium Hyperpolarization-activated Cyclic Nucleotide-Gated Channel 4

Family:
Hyperpolarization-activated cyclic nucleotide-gated channels

Subgroups:
Four different members HCN1-HCN4

Topology:
The channel protein contains six transmembrane domains (S1–S6), four subunits form a functional channel, homotetramers and heterotetramers are possible

Function:
Nonselective gated cation channels, referred to as pacemaker channels, rhythmicity in brain and heart cells

Publications

2019 - Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

Port-a Patch and Internal Perfusion Publication in JCI Insight (2019)

Authors:
Hammelmann, V., Stieglitz, M.S., Hülle, H., Le Meur, K., Kass, J., Brümmer, M., Gruner, C., Rötzer, R.D., Fenske, S., Hartmann, J., Zott, B., Lüthi, A., Spahn, S., Moser, M,, Isbrandt, D., Ludwig, A., Konnerth, A., Wahl-Schott, C., Biel M.

2012 - Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

Port-a-Patch publication in Journal of Biological Chemistry (2012)

Authors:
Zong X., Krause S., Chen C.C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C., Biel M.