Kir1.1 | ROMK1 I Potassium Voltage-Gated Channel Subfamily J Member 1
Inward-rectifier potassium ion channel
Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1
The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily
Kir1.1 Background Information
Kir1.1 is also known as ROMK (renal outer medullary potassion channel) or ATP-sensitive inward rectifier potassium channel 1. It is an ATP-dependent potassium channel that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron.
Kidney and pancreatic islets, lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
Plays a major role in potassium homeostasis in the kidney
Bartter syndrome 2, Antenatal Bartter Syndrome
Associated subunit: NHERF2 (Sodium-hydrogen exchange regulatory cofactor 2). Interacts with serum/glucocorticoid regulated kinase 1 (SGK1), Solute carrier family 9, subfamily A (SLC9A3R2/NHERF2), CFTR, WNK lysine deficient protein kinase 4, SH3 domain containing ring finger 1
Barium, ATP, glimepiride, glycodiazine, minoxidil, tolbutamide, glyburide, tertiapin-Q
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526