Kir5.1 | Potassium Voltage-Gated Channel Subfamily J Member 16

K_ir5.1 is a G-protein activated inward rectifier potassium channel, involved in the regulation of fluid and pH balance. In the kidney, together with K_ir4.1, the channel mediates basolateral K⁺ recycling in distal tubules; this process is critical for Na⁺ reabsorption at the tubules.

Gene:
KCNJ16

Human Protein:
UniProt Q9NPI9

Tissue:
Widely expressed, with highest levels in adult and fetal kidney (in the proximal and distal convoluted tubules, not in glomeruli nor collecting ducts), in the brain the channel is expressed ind neurons and glial cells.

Function/ Application:
Mediates basolateral K⁺ recycling in distal tubules

Pathology:
Sesame Syndrome, Campomelic Dysplasia, Body dysmorphic disorder, corneal dystrophy, schnyder type, thyrotoxic periodic paralysis

Interaction:
Forms heteromers with K_ir5.1. Interacts with K_ir2.1 and K_ir4.2 (may form heterodimers), Gamma-aminobutyric acid B receptor 1 and 2, GNB3, GNG13, GNGT1, Guanylate kinase 1, DLG2, GNGT2icorandil, Glyburide

Assays:
Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526