Kir7.1 | Potassium Voltage-Gated Channel Subfamily J Member 13

Family:
Inward-rectifier potassium ion channel

Subgroups:
Seven families channels demonstrate robust inward rectification: K_ir1.1; K_ir2.1 - K_ir2.4; K_ir3.1 - K_ir3.4, K_ir4.1 - K_ir4.2; K_ir5.1, K_ir6.1 - K_ir6.2; K_ir7.1

Topology:
The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily

Kir7.1 Background Information

K_ir7.1 is a non voltage-gated wealkly inwardly rectifying potassium channel. It has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

Gene:
KCNJ13

Human Protein:
UniProt O60928

Tissue:
Predominantly expressed in thyroid follicular cells, choroid plexus, small intestine and moderately in the kidney, stomach, located in the basolateral membrane of follicular cells, in the apical membrane of epithelia. Expressed ind all regions of the central nervous system with the exception of spinal cord

Function/ Application:
Putatively involved in the functional coupling between the channel and Na⁺K⁺ ATPase

Pathology:
Snowflake vitreoretinal degeneration (SVD), Leber congenital amaurosis 16 (LCA16), Aplasia/Hypoplasia of the cerebellar vermis, abnormality of retinal pigmentation

Interaction:
CFTR, C1QBP, CATSPER1, ABCC8

Modulator:
4-AP, Glyburide, Nicorandil, Tertiapin-Q

Assays:
Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526

Publications

2011 - Development of a selective small-molecule inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

Patchliner publication in Molecular Pharmacology (2011)

Authors:
Bhave G., Chauder B.A., Liu W., Dawson E.S., Kadakia R., Nguyen T.T., Lewis L.M., Meiler J., Weaver C.D., Satlin L.M., Lindsley C.W., Denton J.S.

2009 - High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1

Patchliner publication in Molecular Pharmacology (2009)

Authors:
Lewis L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D., Denton J.S.