KV1.2 | Shaker Related Potassium Channel Member 2

Potassium channels

Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.

KV1.2 Background Information

KV1.2 is a delayed rectifier voltage gated potassium channel found in almost all cell types. This member of the shaker-related subfamily contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It's function is to allow nerve cells to efficiently repolarize following an action potential. It mainly contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. KCNA2 (gene) can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNA2 or other alpha subunits, creating a functionally diverse range of channel complexes.


Human Protein:
UniProt P16389

Brain (neurons), cardiac and smooth muscle tissue, retina, pancreas

Function/ Application:
Excitability of neurons and muscle

Epileptic Encephalopathy, Undetermined Early-Onset Epileptic Encephalopathy, ataxia, neuropathic pain

Forms homotertamers or heterotetramers with Kv1.1, Kv1.5, Kvβ1, Kvβ2. Also interacts with PSD95, RhoA, Caspr2, SAP97, SNAP95 I 

Margatoxin, Dendrotoxin, Tityustoxin Kα Hongotoxin-1, Urotoxin

Patch Clamp: whole cell mode

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Useful website:


2020 - Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

icon pl   Patchliner publication in Biochemical Pharmacology (2020)

Luna-Ramirez K., Csoti A., McArthur J.R., Chin Y.K.Y., Anangi R., del Carmen Najera R., Possani L.D., King G.F., Panyi G., Yu H., Adams D.J., Finol-Urdaneta R.K.

2019 - A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

 icon pl   Patchliner publication in Frontiers in Cellular Neuroscience (2019)

Ranjan R., Logette E., Marani M., Herzog M., Tâche V., Scantamburlo E., Buchillier V., Markram H.

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