2008 - Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

icon pap  Port-a-Patch publication in Bioorganic & Medicinal Chemistry Letters (2008)

Authors: 
Cianci J., Baell J.B., Flynn B.L., Gable R.W., Mould J.A., Paul D., Harvey A.J.

 

Journal: 
Bioorganic & Med. Chem. Lett. (2008) 18:2055–2061


Abstract: 

Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.


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