KV1.3 - Internal Application of TEA and Quinidine

icon pap   Port-a-Patch data and applications:p25 1 Kv1,3

KV1.3 current was blocked by the internal application of increasing concentrations of quinidine (left) or TEA+ (right). For quinidine the IC50 was determined as 15 μM (literature value external application 14 μM) and for TEA+ the IC50 was determined as 0.9 ± 0.3 mM (n = 3) (literature value internal application 0.6 mM).


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