• KV1.5

    KV1.5 measured on the SyncroPatch 394PE

KV1.5 | Shaker Related Potassium Channel Member 5

Potassium channels

Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.

KV1.5 Background Information

KV1.5 belongs to the delayed rectifier class. It can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. The function of KV1.5 restores the resting membrane potential of beta cells after depolarization and thereby contributes to the regulation of insulin secretion. Expressed in atrial myocytes KV1.5 forms the IKur current. It is also expressed in the human ventricle where it is possible that it contributes to the K+ current through formation of heteromultimeric Potassium channels with other KV-alpha subunits.


Human Protein:
UniProt P22460

Cardiac and smooth muscle, beta cells, colon, aorta, stomach and pulmonary artery, neurons, kidney

Function/ Application:
Excitability, repolarization cardiac action potential, insulin secretion, pulmonary vascular function, cardiac IKur current

Atrial fibrillation type 7, familial atrial fibrillation, insulinoma, sudden cardiac death, prolonged PR interval, palpitations, prolonged QTc interval, autosomal dominant inheritance

KVβ1, KVβ2, KVβ3.1, SAP97 , Src Tyrosine Kinase, caveolin 1, caveolin 3, α-actinin-1, α-actinin-2, DLG1, DLG4, CACNA1C

α-linolenic acid, TEA, 4-AP, nifedipine, flecainide, bupivacaine, E-4031, XE 991 dihydrochloride

Patch Clamp: whole cell, temperature control

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Data and Applications

KV1.5 - Dose response curve of 4-AP

icon sp96   KV1.5 Data 3845PESyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.

Screenshots of the PatchControl 384 software showing a dose-response curve of 4-AP on KV1.5 stably transfected cells. Measured on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384) using multi-hole chips (4 holes per well), the success rate of completed exeriments was 100%. The IC50 value of 160 µM corresponds well to literature (IC50 4-AP: 270 µM; Gutman et al., Pharmacological Reviews 57: 473-508, 2005). 


2020 - Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

icon pl   Patchliner publication in Biochemical Pharmacology (2020)

Luna-Ramirez K., Csoti A., McArthur J.R., Chin Y.K.Y., Anangi R., del Carmen Najera R., Possani L.D., King G.F., Panyi G., Yu H., Adams D.J., Finol-Urdaneta R.K.

2019 - A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

 icon pl   Patchliner publication in Frontiers in Cellular Neuroscience (2019)

Ranjan R., Logette E., Marani M., Herzog M., Tâche V., Scantamburlo E., Buchillier V., Markram H.

2018 - Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

icon pap   Port-a-Patch publication in Circulation (2018)

Yao C., Veleva T., Scott L., Cao S., Li L., Chen G., Jeyabal P., Pan X., Alsina K.M., Abu-Taha I., Ghezelbash S., Reynolds C.L., Shen Y.H., LeMaire S.A., Schmitz W., Müller F.U., El-Armouche A., Eissa N.T., Beeton C., Nattel S. , Wehrens X.H.T., Dobrev D., Li N.

2017 - Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

icon pap   Port-a-Patch publication in Clinical Immunology (2017)

Tanner M.R., Tajhya R.B., Huq R., Gehrmann E.J., Rodarte K.E., Atik M.A., Norton R.S., Pennington R.W., Beeton C.

2013 - A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

icon pap   Port-a-Patch publication in PLoS ONE (2013)

Rashid M.H., Heinzelmann G., Huq R., Tajhya R.B., Chang S.C., Chhabra S., Pennington M.W., Beeton C., Norton R.S., Kuyucak S.

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.