KV10.1 | EAG1 | Eag Related Potassium Channel Member 1

Potassium channels

Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.


KV10.1 Background Information

KV10.1, also known as human ether à-go-go1 protein or EAG1, is the pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Upon a depolarization, a slowly activating noninactivating outward current is elicited. Upon repolarization a small tail current occurs. EAG1 is expressed almost exclusively in brain tissue and is involved in cell excitability, memory processes, and cell proliferation. Their expression in over 70% of human tumours makes them an attractive diagnostic and therapeutic target treatment of prostate cancer: The Eag1 K+ channel is especially thought to be involved in the pathophysiological processes of prostate cancer, and is expected to be a valuable target for the diagnosis and treatment of prostate cancer.


Human Protein:

Brain (cortex, hippocampus, caudate, putamen, amygdala and weakly in substantia nigra, retina), kidney, lung, pancreas, bone marrow mesenchymal stem cells, heart

Function/ Application:
Cell proliferation, cell excitability, transformation of epithelial cells, mediates IKNI current in myoblasts

Cancer, Temple-Baraitser Syndrome, Zimmermann-Laband Syndrome 1, myasthenic syndrome, congenital 5 , acute contagious conjunctivitis

KV2.1, epsin, KCR1, ICA, KV10.2, ALG10B, CaM, slop, RABEP1, CTTN

Quinidine, astemizole, E-4031, terfenadine, dofetilide, haloperidol, imipramine,

Patch Clamp: whole cell, state- and use-dependance, temperature control

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Data and Applications

hEAG (hKv10.1) - Internal Application of TEA

application heag 1

icon pap   Port-a-Patch data and applications:
Data were kindly provided by Walter Stühmer, MPI for exp. Med., Göttingen.

Block of hEAG whole cell currents after the internal application of 200 µM TEA.



2016 - Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

icon pl  Patchliner publication in Scientific Reports (2016)

Han B., He K., Cai C., Tang Y., Yang L., Heinemann S.H., Hoshi T., Hou S.

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