KV10.1 | EAG1 | Eag Related Potassium Channel Member 1

K_V10.1, also known as human ether à-go-go1 protein or EAG1, is the pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Upon a depolarization, a slowly activating noninactivating outward current is elicited. Upon repolarization a small tail current occurs. EAG1 is expressed almost exclusively in brain tissue and is involved in cell excitability, memory processes, and cell proliferation. Their expression in over 70% of human tumours makes them an attractive diagnostic and therapeutic target treatment of prostate cancer: The Eag1 K⁺ channel is especially thought to be involved in the pathophysiological processes of prostate cancer, and is expected to be a valuable target for the diagnosis and treatment of prostate cancer.

Gene:
KCNH1

Human Protein:
O95259

Tissue:
Brain (cortex, hippocampus, caudate, putamen, amygdala and weakly in substantia nigra, retina), kidney, lung, pancreas, bone marrow mesenchymal stem cells, heart

Function/ Application:
Cell proliferation, cell excitability, transformation of epithelial cells, mediates IK_NI current in myoblasts

Pathology:
Cancer, Temple-Baraitser Syndrome, Zimmermann-Laband Syndrome 1, myasthenic syndrome, congenital 5 , acute contagious conjunctivitis

Interaction:
K_V2.1, epsin, KCR1, ICA, K_V10.2, ALG10B, CaM, slop, RABEP1, CTTN

Modulator:
Quinidine, astemizole, E-4031, terfenadine, dofetilide, haloperidol, imipramine,

Assays:
Patch Clamp: whole cell, state- and use-dependance, temperature control

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508