KV4.2 | Shal Related Potassium Channel Member 2
Family:
Potassium channels
Subgroups:
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)
Topology:
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.
KV4.2 Background Information
Overview:
KV4.2 is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It mediates the major part of the dendritic A-type current ISA in brain neurons. ISA is triggered at membrane potentials that are below the threshold for action potentials. KV4.2 inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KV4.2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac Ito current differs between species; it is mediated by KV4.2 in rodents. In human and other non-rodents KV4.3 may play an equivalent role.
Data Sheet:
Gene:
KCND2
Human Protein:
UniProt Q9NZV8
Tissue:
Brain: in neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons.
Function/ Application:
The channel regulates neuronal excitability in the brain. It prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites.
Pathology:
Autism, epilepsy
Accessory subunits:
Homotetramer or heterotetramer with KCND1 or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4, DPP6, DPP10
Interaction:
DLG1, DLG4, NCS1/FREQ, FLNA, FLNC
Modulator:
Quinidine, phrixotoxin 1, arachidonic acid
Assays:
Patch Clamp: whole cell
Reviews and Links
Recommended Reviews:
Transporter classification database:
Channelpedia:
UniProt:
IUPHAR/PBS:
Publications
2019 - Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3
SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Bioorganic & Medicinal Chemistry (2019)
Authors:
Zoukimian C., Meudal H., De Waard S., Ait Quares K., Nicolas S., Canepari M., Béroud R., Landon C., De Waard M., Boturyn D.
2019 - In vitro and in vivo characterization of a synthetic scorpion toxin AmmTx3, a potent inhibitor of cardiac voltage-gated potassium channel Kv4.2
SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Archives of Cardiovascular Diseases Supplements (2019)
Authors:
Nicolas S., Zoukimian C.,Meuda H., De Waard S., Ait Ouares K., Canepari M., Beroud R., Landon C., De Waard M., Boturyn D.
2019 - A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
Patchliner publication in Frontiers in Cellular Neuroscience (2019)
Authors:
Ranjan R., Logette E., Marani M., Herzog M., Tâche V., Scantamburlo E., Buchillier V., Markram H.