• KV7.1

    Analysis of KV7.1/KCNE co-expressed channels on the Patchliner

KV7.1 (KVLQT) - current-voltage relationship

IKs ApconiX PL IVicon pl   Patchliner data and applications: 
Data kindly provided by ApconiX, UK

KCNQ1/KCNE1 expressed in CHO cells was activated using increasing voltage steps. Shown are traces from an example cell and the normalized current-voltage plot for an average of 8 cells. The IKs current mediated by KCNQ1/KCNE1 started to activate at approximately -20 mV and increased with each voltage step (increment 10 mV). The normalized IV curve was fit using a Boltzmann equation revealing a Vhalf of activation of 25 mV.

 

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