MscL | Large Conductance Mechanosensitive Channel
Bacterial mechanosensitive channels, large conductance mechanosensitive channel
MscL is encoded by trkA. The protein contains two transmembrane helixes (M1 and M2). The channel is a homopentamer of the protein.
Regulation and Function:
MscL is responsible for translating physical forces applied to cell membranes into electrophysiological activities. MscL has a relatively large conductance, 3 nS, making it permeable to ions, water, and small proteins when opened.
Data and Applications