NaK - Non-selective Tetrameric Ion Channels

Non-selective Tetrameric Ion Channels

The NaK channel is a homotetramer with each of the four identical subunits containing transmembrane helices (M1 and M2), an interfacial helix (M0), a pore helix (P), and a selectivity filter to conduct ions.

The NaK channel is prokaryotic non-selective tetrameric ion channel which conducts sodium (Na+) and potassium (K+) ions. The channel contains a transmembrane aqueous pore that transports ions through facilitated diffusion. It maintains the ionic flux across cell membranes with Na+ ions that depolarize the membrane potential and K+ ions that repolarize the membrane potential. The NaK channelcontrols biological functions including coordination of contraction and transport of metal ion cofactors of enzymes.


2016 - Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Communications (2016)

Dhakshnamoorthy B., Rohaim A., Rui H., Blachowicz L., Roux B.

2015 - Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biological Chemistry (2015)

Carrara G., Saraiva N., Parsons M., Byrne B., Prole D.L., Taylor C.W., Smith G.L.

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