NaV1.1 | sodium voltage-gated channel alpha subunit 1
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.1: Background Information
NaV1.1 is a voltage-gated ion channel essential for the generation and propagation of action potentials, and is expressed in nerve, glial cells and muscle. In neurons NaV1.1 is presumably involved in propagating synaptic signals from dendrites to soma and in integration of electrical signals within the soma prior to the initiation of axonal action potentials. NaV1.1 is the primary voltage-gated Na+ channel in several clases of GABAergic interneurons, and its reduced activity leads to reduced excitability and decreased GABAergic tone. NaV1.1 is TTX-sensitive.
Brain (neurons, glia)
Excitability of neurons, generation of action potentials
Pain, epilepsy (SMEI, GEFS+), migraine (FHM3), Rasmussen's encephalitis, autism, Dravet syndrome, Lennox-Gastaut syndrome, Panayiotopoulos syndrome, Doose syndrome
b1, b2, b3, b4
Alpha-1 syntrophin, β1 subunit, β2 subunit, calmodulin, Ca2+, FHF4
Tetrodotoxin, ATX-II, Bc-III, AFT-II, Lidocaine
Patch Clamp: whole cell, room temperature, State- and use-dependence
NaV channel analysis requires GigaOhm seals and a stable and low access resistance
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005