NaV1.2 | sodium voltage-gated channel alpha subunit 2

Sodium channels


Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.

NaV1.2: Background Information

NaV1.2 is primarily expressed in unmyelinated axons and dendrites. Besides other voltage gated sodium channels but predominately, NaV1.2 and NaV1.6 subunits are co-expressed within a single hair cell. NaV1.2 ion channels are regulated by neutrotransmitters that act through G-protein coupled receptors and activate protein kinase A such dopamine, acetylcholine and serotonin. NaV1.2 is sensitive to TTX.


Human Protein:
UniProt Q99250

Brain (neurons, microglia), utricular hair cells, corti organ

Function/ Application:
Excitability of neurons, generation of action potentials

Autism, epilepsy (EIEE11, BFNIS), late ataxia, pain, myoclonus, multiple sclerosis, Seizures, benign familial infantile, 3, Ohtahara syndrome, Infantile Spasms

Ankyrin G, β1 subunit, β2 subunit, calmodulin, Nedd4-2

Tetrodotoxin, saxitoxin , β-scorpion toxin Css-IV, veratridine, α-scorpion toxin, ATX-II

Patch Clamp: whole cell, room temperature, State- and use-dependence

Patch clamp: NaV channel analysis requires GigaOhm seals and a stable and low access resistance

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005 


2021 - The Schizophrenia Variant V1282F in SCN2A Causes Functional Impairment of NaV1.2

icon sp96 SyncroPatch Publication in Journal of Schizophrenia Research (2021)

Kohlnhofer B., Liu Y., Woodruff G., Lovenberg T., Kohlnhofer B., Liu Y., Woodruff G., Bonaventure P., and Harrington AW.

2020 - Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in Science Translational Medicine (2020)

Heyne H.O., Baez-Nieto D., Iqbal S., Palmer D., Brunklaus A., Johannesen K.M., Lauxmann S., Lemke J.R., Møller R.S., Pérez-Palma E., Scholl U., Syrbe S., Lerche H., May P., Lal D., Campbell A.J., Pan J., Wang H.-R., Daly M.J.

2020 - Fenamates Inhibit Human Sodium Channel Nav1.2 and Protect Glutamate-Induced Injury in SH-SY5Y Cells

icon pap   Port-a-Patch publication in Cellular and Molecular Neurobiology (2020)

Sun J.F., Zhao M.Y., Xu Y.J., Su Y., Kong X.H., Wang Z.Y.

2017 - High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in PLoS One (2017)

Li T, Lu G, Chiang E.Y., Chernov-Rogan T., Grogan J.L., Chen J.

2014 - Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

icon pl  Patchliner publication in Neurobiology of Disease (2014)

Oliva M.K., McGarr T.C., Beyer B.J., Gazina E., Kaplan D.I., Cordeiro L., Thomas E., Dib-Hajj S.D., Waxman S.G., Frankel W.N., Petrou S.

2012 - Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

icon pap   Port-a-Patch publication in Biochemical Pharmacology (2012)

Vetter I., Dekan Z., Knapp O., Adams D.J., Alewood P.F., Lewis R.J.

2010 - Propranolol blocks cardiac and neuronal voltage-gated sodium channels

icon pl  Patchliner publication in Frontiers in Pharmacology (2010)

Wang D.W., Mistry A.M., Kahlig K.M., Kearney J.A, Xiang J., George Jr. A.L.

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