NaV1.2 | sodium voltage-gated channel alpha subunit 2

Family:
Sodium channels

Subgroups:
NaV1.1-1.9

Topology:
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.

NaV1.2: Background Information

NaV1.2 is primarily expressed in unmyelinated axons and dendrites. Besides other voltage gated sodium channels but predominately, NaV1.2 and NaV1.6 subunits are co-expressed within a single hair cell. NaV1.2 ion channels are regulated by neutrotransmitters that act through G-protein coupled receptors and activate protein kinase A such dopamine, acetylcholine and serotonin. NaV1.2 is sensitive to TTX.

Gene:
SCN2A

Human Protein:
UniProt Q99250

Tissue:
Brain (neurons, microglia), utricular hair cells, corti organ

Function/ Application:
Excitability of neurons, generation of action potentials

Pathology:
Autism, epilepsy (EIEE11, BFNIS), late ataxia, pain, myoclonus, multiple sclerosis, Seizures, benign familial infantile, 3, Ohtahara syndrome, Infantile Spasms

Interaction:
Ankyrin G, β1 subunit, β2 subunit, calmodulin, Nedd4-2

Modulator:
Tetrodotoxin, saxitoxin , β-scorpion toxin Css-IV, veratridine, α-scorpion toxin, ATX-II

Assays:
Patch Clamp: whole cell, room temperature, State- and use-dependence

Particularities:
Patch clamp: NaV channel analysis requires GigaOhm seals and a stable and low access resistance

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005 

Publications

2014 - Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

icon pl  Patchliner publication in Neurobiology of Disease (2014)

Authors: 
Oliva M.K., McGarr T.C., Beyer B.J., Gazina E., Kaplan D.I., Cordeiro L., Thomas E., Dib-Hajj S.D., Waxman S.G., Frankel W.N., Petrou S.

2012 - Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

icon pap   Port-a-Patch publication in Biochemical Pharmacology (2012)

Authors: 
Vetter I., Dekan Z., Knapp O., Adams D.J., Alewood P.F., Lewis R.J.

2010 - Propranolol blocks cardiac and neuronal voltage-gated sodium channels

icon pl  Patchliner publication in Frontiers in Pharmacology (2010)

Authors: 
Wang D.W., Mistry A.M., Kahlig K.M., Kearney J.A, Xiang J., George Jr. A.L.

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