NaV1.2 | sodium voltage-gated channel alpha subunit 2
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.2: Background Information
NaV1.2 is primarily expressed in unmyelinated axons and dendrites. Besides other voltage gated sodium channels but predominately, NaV1.2 and NaV1.6 subunits are co-expressed within a single hair cell. NaV1.2 ion channels are regulated by neutrotransmitters that act through G-protein coupled receptors and activate protein kinase A such dopamine, acetylcholine and serotonin. NaV1.2 is sensitive to TTX.
Brain (neurons, microglia), utricular hair cells, corti organ
Excitability of neurons, generation of action potentials
Autism, epilepsy (EIEE11, BFNIS), late ataxia, pain, myoclonus, multiple sclerosis, Seizures, benign familial infantile, 3, Ohtahara syndrome, Infantile Spasms
Ankyrin G, β1 subunit, β2 subunit, calmodulin, Nedd4-2
Tetrodotoxin, saxitoxin , β-scorpion toxin Css-IV, veratridine, α-scorpion toxin, ATX-II
Patch Clamp: whole cell, room temperature, State- and use-dependence
Patch clamp: NaV channel analysis requires GigaOhm seals and a stable and low access resistance
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005