NaV1.3 | sodium voltage-gated channel alpha subunit 3

Sodium channels


Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.


NaV1.3: Background Information

NaV1.3 is abundantly expressed in neuronal tissues during embryonic and neonatal stages of development and is rare in adult tissues. After axonal transection, NaV1.3 is upregulated in dorsal root ganglia (DRG) neurons adding to the evidence that upregulation of NaV1.3 may play a role in rendering axotomized DRG neurons hyperexcitable, thus contributing to neuropathic pain. It is thought that the fast activation and inactivation kinetics of NaV1.3, together with its rapid repriming kinetics and persistent current component, contributes to the development of spontaneous ectopic discharges and sustained rates of firing characteristics of injured sensory nerves. NaV1.3 is TTX sensitive.


Human Protein:
UniProt Q9NY46

Brain neurons, peripheral neurons, injured neurons, spinal cord, heart

Function/ Application:
Excitability of neurons, generation of action potentials

Familial autism, deafness, epilepsy, pain

Contactin, β1 subunit, β3 subunit, β8 subunit, calmodulin, LRP, C1D

Tetrodotoxin, AFT-II, Vinpocetine, Flecainide, Lidocaine

Patch Clamp: whole cell, room temperature, State- and use-dependence

NaV channel analysis requires GigaOhm seals and a stable and low access resistance

Recommended Reviews:
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005 


2012 - Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

icon pap   Port-a-Patch publication in Biochemical Pharmacology (2012)

Vetter I., Dekan Z., Knapp O., Adams D.J., Alewood P.F., Lewis R.J.

2010 - Propranolol blocks cardiac and neuronal voltage-gated sodium channels

icon pl  Patchliner publication in Frontiers in Pharmacology (2010)

Wang D.W., Mistry A.M., Kahlig K.M., Kearney J.A, Xiang J., George Jr. A.L.

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