NaV1.5 - Lidocaine Dose Response

   SyncroPatch384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells were kindly provided by EMD Millipore

Na_V1.5 expressed in HEK293 cells recorded on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384). The concentration response curves for lidocaine block of Na_V1.5 were constructed at different holding potentials (as indicated) either using a single concentration of compound per cell (solid lines) or cumulative concentration response curves (dashed line). The IC₅₀ for lidocaine was shifted by a factor of 35 when holding potential was changed from -120 mV to -80 mV.

Back to Overview