NaV1.7 - Frequency Dependent Inhibition

  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were kindly provided by Anaxon.

The frequency dependent inhibition of Tetracaine (5 µM, 15 µM and 50 µM) on Na_V1.7 currents were investigated. Measured on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384), the whole cell patch methodology and single-hole chips were used. The IC₅₀ value determined from the first pulse of the pulse train was calculated as 41.8 µM, from the second pulse as 9.9 µM and from the 10^th pulse as 3.0 µM. 

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