NaV1.8 - I/V Characteristics

ND723 Nav18 Syncro IV Figureicon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) data and applications: 

The ND7-23 cells were kindly provided by Millipore.

A Raw traces from an exemplar cell recorded on the SyncroPatch 96. Shown are current responses to increasing voltage steps from -60 to +60 mV.
B Average current-voltage plot, Vhalf of activation was 12 mV (n = 32).
C Average inactivation plot, Vhalf of inactivation was -27 mV (n = 32). Nav1.8 currents started to activate at about -30 mV, peak response was elicited between 20 and 30 mV and Vhalf of activation was 12 mV. The Vhalf of inactivation was -27 mV in good agreement with the literature.

 

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