nAChRa7 | nicotinic acetylcholine receptor alpha 7
Family:
Acetylcholine Receptors
Subgroups:
The family has been devided into nicotinic acetylcholine receptors (ionotropic channels) and muscarinic acetylcholine receptors (metabotropic G-protein coupled receptors). Both subgroups are sensitive to acetylcholine.
Topology:
Nicotinic acetylcholine receptors: As typical cys-loop receptors, acetylcholine receptor subunits contain four transmembrane spanning domains TM1-TM4. Five subunits form a pore, homomeric and heteromeric combinations are possible.17 vertebrate subunits have been identified: α genes: CHRNA1 - CHRNA10; β genes: CHRNB1 . CHRNB4, as well as CHRND (delta), CHRNE (epsilon), CHRNG (gamma)
Muscarinic acetylcholine receptors: 5 receptors have been described (M1 - M5), encoded by the 5 genes CHRM1 - CHRM5. These proteins contain seven transmembrane regions and do not form homo or heteromers.
AChRα7: Background Information
Gene:
CHRNA7
Human Protein:
UniProt P36544
Tissue:
Brain, retina, spinal cord, peripheral neuronal tissues, including neurons of mammalian sympathetic ganglia, parasympathetic ganglia, sensory neurons such as the trigeminal ganglia and adrenal chromaffin cells
Function/ Application:
Mediates effects of acetylcholine and nicotine in specific regions of the brain, retina and spinal cord
Pathology:
Schizophrenia, Alzheimer's disease, Parkinson's, Tourette's Syndrome, depression
Accessory subunits:
Interaction:
Modulator:
Antagonists: DHβE, mecamylamine, α-bungarotoxin, α-conotoxin ImI, methyllycaconitine, α-conotoxin ArIB; Positive allosteric modulators: A-867744, LY2087101, NS1738, JNJ1930942, PNU-120596
Assays:
Patch Clamp: whole cell, room temperature, physiological temperature
Cell systems:
Stably-transfected GH4C1 cell line
Recommended Reviews:
Physiol Rev 89: 73–120, 2009; doi:10.1152/physrev.00015.2008, Albuquergue et al; Nicotinic acetylcholine receptors, in: Burger’s Medicinal Chemistry, Vol II Drug Discovery and Drug Development, Chapter 11, pp 357-405. Ed. Abraham, D., J. Wiley, New York., Colquhoun et al.
Reviews and Links
Recommended Reviews:
Transporter classification database:
UniProt:
IUPHAR/PBS:
Application Notes
Data and Applications
Publications