Ryanodine Receptors | RyRs
Ryanodine receptor family
Topology and Members:
Three members are known in human:
RyR1: Is primarily expressed in skeletal muscle
RyR2: Is primarily expressed in myocardium
RyR3: Is expressed more widely, but especially in the brain
The channels contain six transmembrane helices, are composed of mostly homotetramers (heterotetramers are as well described) and complex with further proteins which modulate the channel functions.
Ryanodine receptors form a class of intracellular calcium channels in various forms of excitable animal tissue. Located in the sarcoplasmic/ endoplasmic reticulum membrane, the channels mediate the release of calcium ions from intracellular stores into the cytoplasm.
Data and Applications