SERCA - Sarco/Endoplasmic Reticulum Calcium-ATPase
Family:
P-type ATPase (P-ATPase) Superfamily
Subgroups:
P-type ATPases can be divided into five subfamilies (types)
Type I consists of the transition/heavy metal ATPases.
Type II ATPases (specific for Na+,K+, H+ Ca2+, Mg2+ and phospholipids) predominate in eukaryotes. SERCA and Na+/K+ ATPases are member of this group.
There are 3 major paralogs, SERCA1-3, which are expressed at various levels in different cell types: SERCA1 - SERCA3, encoded by the genes ATP2A1 - ATP2A3.
Type III ATPases contains the plasma membrane H+-ATPases from plants and fungi.
Type IV ATPases have been shown to be involved in the transport of phospholipids
Type V ATPases have unknown specificity.
Topology:
Many of these protein complexes are multisubunit with a large subunit serving the primary ATPase and ion translocation functions. Many eukaryotic P-type ATPases are monomeric or homodimeric enzymes of the catalytic subunit that hydrolyzes ATP. They contain the aspartyl phosphorylation site and catalyzes ion transport. The Na+/K+-ATPases, the Ca2+-ATPases and the (fungal) H+-ATPases of higher organisms exhibit 10 transmembrane α helical spanners (TMSs).
Function:
P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation of a key conserved aspartate residue within the pump and their energy source, adenosine triphosphate (ATP). Most members of this transporter superfamily catalyze cation uptake and/or efflux, however one subfamily is involved in flipping phospholipids to maintain the asymmetric nature of the biomembrane.
Publications
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in ChemMedChem(2021)
Authors:
Sordi G., Goti A., Young H.S., Palchetti I., Tadini‐Buoninsegni F.
SURFE²R 96SE and
SURFE²R N1 Review in Molecules (2020)
Authors:
Tadini-Buoninsegni F.
SURFE²R 96SE and
SURFE²R N1 Review article in Frontiers in Sensors (2020)
Authors:
Tadini-Buoninsegni F.,Palchetti I.
Port-a-Patch publication in American Journal of Translational Research (2020)
Authors:
Han L., Wu A., Li Q., Xia Z., Wu Y., Hong K., Xia Z., Li J.
SURFE2R N1 and
Orbit 16 publication in Frontiers in Pharmacology (2019)
Authors:
Dondapati S.K., Lübberding H., Zemella A., Thoring L., Wüstenhagen D.A., Kubick S.
SURFE²R 96SE Review article in Frontiers in Molecular Biosciences (2018)
Authors:
Tadini-Buoninsegni F., Smeazzetto S., Gualdani R., Moncelli M.R.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in IUBMB Life (2017)
Authors:
Tadini-Buoninsegni F., Smeazzetto S.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in Metallomics (2017)
Authors:
Tadini-Buoninsegni F., Sordi G, Smeazzetto S, Natile G, Arnesano F.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in Journal of Biological Chemistry (2017)
Authors:
Smeazzetto S., Armanious G.P., Moncelli M.R., Bak J.J., Lemieux M.J., Young H.S., Tadini-Buoninsegni F.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in Nature Scientific Reports (2015)
Authors:
Tadini-Buoninsegni F., Moncelli M.R., Peruzzi N., Ninham B.W., Dei L., Lo Nostroa P.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in EMBO Reports (2015)
Authors:
Mattle D., Zhang L., Sitsel O., Pedersen L.T., Moncelli M.R., Tadini-Buoninsegni F., Gourdon P., Rees D.C., Nissen P., Meloni G.
SURFE²R N1 publication in ChemMedChem (2014)
Authors:
Sadafi F.Z., Massai L., Bartolommei G., Moncelli M.R., Messori L., Tadini-Buoninsegni F.
SURFE²R N1 publication in Langmuir (2013)
Authors:
Sacconi A., Moncelli M.R., Mergheri G., Tadini-Buoninsegni F.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in Journal of Biological Chemistry (2012)
Authors:
Lewis D., Pilankatta R., Inesi G., Bartolommei G., Moncelli M.R., Tadini-Buoninsegni F.
SURFE²R ONE (a predecessor model of SURFE²R N1) publication in Langmuir (2009)
Authors:
Bartolommei G., Moncelli M.R., Rispoli G., Kelety B., Tadini-Buoninsegni F.
SURFE²R-technology (custom-built system) publication in Biophysical Journal (2004)
Authors:
Tadini Buoninsegni F., Bartolommei G., Moncelli M.R., Inesi G., Guidelli R.
SURFE²R-technology (custom-built system) publication in Bioelectrochemistry (2004)
Authors:
Bartolommei G., Buoninsegni F.T., Moncelli M.R.
SURFE²R-technology (custom-built system) publication in Biophysical Journal (1993)
Authors:
Seifert K., Fendler K., Bamberg E.
Data and Applications
a. P-bond hydrolysis driven transporters