SGLT1 - Sodium/Glucose Cotransporter 1 - SLC5A1
Family:
Glucose transporters
Subgroups:
Two families of glucose transporter have been identified:
GLUT family: The facilitated diffusion glucose transporter family, also known as 'uniporters'. Members are GLUT1 - GLUT14
SGLT family: The sodium-dependent glucose transporter family, also known as 'cotransporters' or 'symporters. The most well known members are SGLT1 and SGLT2. In addition to SGLT1 and SGLT2, there are five other members in the human protein family SLC5A, several of which may also be sodium-glucose transporters.
Topology:
GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side.
SGLT proteins contain 14 transmembrane regions.
SGLT1: Background Information
Gene:
SLC5A1
Human Protein:
UniProt P13866
Tissue:
lumen of the small intestine, kidney, parotid glands, submandibular glands and in the heart
Function/ Application:
The role of the sodium-glucose cotransporters is to not only absorb glucose, but to also absorb sodium and to then reabsorb the sodium and glucose from the tubule of the nephron
Pathology:
glucose-galactose malabsorption disease
Interaction:
PAWR
Substrates:
Glucose, galactose
Assays:
SURFE2R transporter assays
Cell systems:
Stably-transfected GH4C1 cell line
Recommended Reviews:
Wright EM, Loo DD, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Mackenzie B, Boorer K, Zampighi G (1994). 'Active' sugar transport in eukaryotes. The Journal of Experimental Biology. 196: 197–212.
Data and Applications
Posters
2020 - A novel approach to detect electrogenic transporter activity in intact cells applied to investigate iPSC derived cardiomyocytes and neurons
SURFE²R N1 and 
SURFE²R 96SE poster, 64th Annual Meeting of the Biophysical Society 
(1.6 MB)
2017 - An emerging technique for the characterization of transport proteins: SSM-based electrophysiology
SURFE²R N1 and 
SURFE²R SE96 poster, 19th IUPAB / 11th EBSA congress 2017 (3.3 MB)
2015 - Studying Electrogenic Transporters of the SLC Family in a Parallel Way Utilizing Solid Supported Membrane Technology
SURFE²R N96 poster (a predecessor model of the SURFE²R 96SE) Biophysics 2015 (0.8 MB)
