TASK-2 | K2P5.1 | Potassium Channel Subfamily K Member 5

Tandem-Pore Domain Potassium Channels

Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel (TRESK)
15 members: K2P1.1 (TWIK-1); K2P2.1 (TREK-1); K2P3.1 (TASK-1); K2P4.1 (TRAAK); K2P5.1 (TASK-2); K2P6.1 (TWIK-2); K2P7.1; K2P9.1 (TASK-3); K2P10.1 (TREK-2); K2P12.1 (THIK-2); K2P13.1 (THIK-1); K2P15.1 (TASK-5); K2P16.1 (TALK-1); K2P17.1 (TASK-2, TASK-4); K2P18.1 (TRIK, TRESK);

The channel protein contains four transmembrane domains, which form two pore loops between domains 1–2 and 3–4. Two subunits associate to form a dimer with bilateral symmetry around the pore. Homodimers and heterodimers are possible.

Several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins


2017 - 14-3-3 proteins regulate K2P5.1 surface expression on T lymphocytes

icon pl  Patchliner publication in Traffic (2017)

Fernández-Orth J., Ehling P., Ruck T., Pankratz S., Hofmann M.,Landgraf P., Dieterich D.C., SmallaK.-H., Kähne T., Seebohm G., Budde T., Wiendl H., Bittner S., Meuth S.G.

2016 - The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells

icon pl  Patchliner publication in American Journal of Physiology - Cell Physiology (2016)

Afzali A.M., Ruck T., Herrmann A.M., Iking J., Sommer C., Kleinschnitz C., Preuβe C., Stenzel W., Budde T., Wiendl H., Bittner S., Meuth S.G.

2016 - Human T cells in silico: Modelling their electrophysiological behaviour in health and disease

icon pl  Patchliner publication in Journal of Theoretical Biology (2016)

Ehling P., Meuth P., Eichinger P., Hermann A.M., Bittner S., Pawlowski M., Pankratz S., Herty M., Budde T., Meuth S.G.

2015 - The two-pore domain K2P channel TASK2 drives human NK-cell proliferation and cytolytic function

icon pl  Patchliner publication in European Journal of Immunology (2015)

Schulte-Mecklenbeck A., Bittner S., Ehling P., Döring F., Wischmeyer E., Breuer J., Herrmann A.M., Wiendl H., Meuth S.G., Gross C.C.

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