TREK-2 | Potassium Channel Subfamily K Member 10

Family:
Tandem-Pore Domain Potassium Channels

Subgroups:
Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel (TRESK)
15 members: K2P1.1 (TWIK-1); K2P2.1 (TREK-1); K2P3.1 (TASK-1); K2P4.1 (TRAAK); K2P5.1 (TASK-2); K2P6.1 (TWIK-2); K2P7.1; K2P9.1 (TASK-3); K2P10.1 (TREK-2); K2P12.1 (THIK-2); K2P13.1 (THIK-1); K2P15.1 (TASK-5); K2P16.1 (TALK-1); K2P17.1 (TASK-2, TASK-4); K2P18.1 (TRIK, TRESK);

Topology:
The channel protein contains four transmembrane domains, which form two pore loops between domains 1–2 and 3–4. Two subunits associate to form a dimer with bilateral symmetry around the pore. Homodimers and heterodimers are possible.

Regulation:
Several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins

Publications

2017 - Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Structure (2017)

Authors: 
Arya P, Jarerattanachat V., Clausen M.V., Schewe M., McClenaghan C., Argent L., Conrad L.J., Dong Y.Y., Pike A.C.W., Carpenter E.P., Baukrowitz T., Sansom M.S.P., Tucker S.J.

2017 - Asymmetric mechanosensitivity in a eukaryotic ion channel

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in PNAS (2017)

Authors:
Clausen M.V., Jarerattanachata V., Carpenterc E.P., Mark S. , Sansomb P., Tucker S.J.

2015 - K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

icon pap  Port-a-Patch publication in Science (2015)

Authors: 
Dong Y.Y., Pike A.C., Mackenzie A., McClenaghan C., Aryal P., Dong L., Quigley A., Grieben M., Goubin S., Mukhopadhyay S., Ruda G.F., Clausen M.V., Cao L., Brennan P.E., Burgess-Brown N.A., Sansom M.S., Tucker S.J., Carpenter E.P.

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